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The study by Oto, Chenelle, Marchese, and Kacmarek found that smaller patient size, obstructive lung mechanics, and higher system leak decreased the ventilator''s ability to synchronize during NIV. The study also found wide differences between the ventilators tested in their ability to synchronize.

The study “A Comparison of Leak Compensation During Pediatric Noninvasive Ventilation: A Lung Model Study” was published in the February 2014 issue of Respiratory Care.

It is evident in both clinical practice and research that patient-ventilator dysynchrony is far too common. This “tug of war” between the patient and ventilator is associated with adverse effects such as increased WOB, discomfort, increased need for sedation, prolonged ICU stay, and possibly higher mortality rates.